ILMAC Lausanne 3-5 October 2018

Cordouan Technologies will be represented by GMP during the ILMAC show 3-5 october 2018 in lausanne.

Visit ILMAC website and www.gmp.ch.

our new Vasco Kin will be presented.

CLINAM Basel September 2-5 2018

Come and visit our booth at the CLINAM conference (https://clinam.org/ ) held at the Basel Congress center (Switzerland) from September 3rd to 5th.
on Tuesday 4th Sept at 15:15 September oral presentation by our CTO David JACOB on Monitoring of Protein Aggregation in Injectable Vaccines Syringes: a New Direct in Situ & Contactless
Technique – (Hall Samarkand /Satellite 17 b. Presentations on Nanoparticles – Analytics, Methods and Technologies)

 

Monitoring protein aggregation in injectable vaccines syringes

Monitoring protein aggregation in injectable vaccines syringes: a new direct & contact-less technique

David Jacob CTO

Keywords: vaccines, protein, in situ measurement, aggregation

AN01-VASCO Kin – monitoring Protein aggregation in injectable

Aggregation of proteins and active principle ingredients (API) in injectable biopharmaceutical products remains a major concern impacting the stability and usability of a product. Indeed, Protein aggregation can occur during all stages of the lifetime of a protein therapeutic, including expression, refolding, purification,
sterilization, shipping, storage, and delivery processes [1, 2]. The mechanism of protein

aggregation is still not well understood; but it is known that certain manufacturing stages
like formulation composition, presence of microbial or vial contaminants during cell
culture, and storage influence the risk of chemical degradation, which increases the risk
of physical degradation and the formation of aggregates. In particular, it has been shown
that the storage container environment plays a role like in prefilled syringes for example
where leaking silicone oil from the rubber stopper, and glass delamination can induce
aggregates. In a context of more and more stringent international health regulations
about the control of biopharmaceutical products, the in-situ monitoring of the denaturation and degradation process of therapeutic proteins during production and storage can be a key competitive advantage for manufacturers and researchers

NANOSAFE 18 in Grenoble France 5-9 November 2018

Cordouan will be attending Nanosafe 18 in Grenoble. We will be presenting De Long Microscope and our latest DLS syustem Vasco Kin.

Please join us from the 5th to the 9th of November 2018

26th Protein Structure Determination in Industry Meeting, PARIS France

Expedition Guadeloupe _ Cordouan _ NP plastic study

RELEASE OF CORDOUAN TECHNOLOGIES BRAND NEW NANOPARTICLE SIZE ANALYZER VASCO KIN™

CORDOUAN TECHNOLOGIES ANNOUNCES THE RELEASE OF VASCO KIN™ ITS BRAND NEW PARTICLE SIZE ANALYZER. 

Keywords: nanoparticle, particle size analyzer, in situ measurement, kinetic study

The VASCO KIN™ is a new generation of nanoparticle size analyzer combining a unique time-resolved kinetic analysis capability with an optical fiber remote probe for in situ measurement. Based on an innovative proprietary Software Time-Resolved Correlation (STRC) technology, VASCO KIN™ is by far the most accurate and versatile particle size analyzer on the market today, opening the field for new and advanced applications in colloids sciences.

Thanks to its 10 years of experience and expertise in NPs characterization, Cordouan Technologies has chosen the best components & cutting-edge technologies for its VASCO KIN™ (Laser, APD, etc.) allowing the best analysis ever done on NPs size distribution in colloids in a minimum time (few seconds needed for great results).

At the heart of VASCO KIN™, STRC is a fast digital acquisition and data processing system which enables photon-counts storages from the very beginning to the end of the measurement and to transfer data to the embedded PC for continous correlation processing. Thanks to its brand new dedicated software NANO KIN®, it is then possible to build up, in real time, an astonishing accurate size distribution in just few seconds.

Data post-processing: At the end of an experiment, all data are recorded and stored into a timetable. Users can then post-process the data by selecting the appropriate time slots for correlation processing and size analysis, enabling to select the most relevant data (big particles scattering events suppression, no artificial/external influence during the experiment, etc.).

A unique “Time slicing” function allows to create discrete time window analysis with adjustable duration and delay. Building up, in a very accurate way, the Kinetics of an experiment can be done automatically by the NANO KIN® software in just a few clicks and a 2D colormap representation displays size distributions over time (see Figure 1).

Thanks to this technique, analysis of turbid samples, kinetics of fast chemical reaction, study of very small NPs in high dilution, dark and concentrated samples are getting very easy!

 

Major innovations & features

  • In situ & contactless optical fiber remote probe: small footprint, non-invasive
  • Proprietary Time-Resolved correlation for real time Kinetics
  • Frequency stabilized laser & artefact-free APD detector for ultra-fast measurement
  • New embedded software dedicated to kinetics analysis: NANO KIN®

Benefits

  • Versatile: can be adapted to various environments & configurations (glass capillaries, auto-clave & reactor, hermetically sealed vials, mili-fluidic device, etc.)
  • Measurement of diluted and/or subnanometer samples.
  • High resolution kinetic monitoring (time resolution: down to 200 ms)
  • No moving parts – easy maintenance, reliable
  • High throughput measurements
Expedition Guadeloupe _ Cordouan _ NP plastic study

NANOPLASTICS/ CORDOUAN TECHNOLOGIES, PARTNER OF THE CAPP “LITTORAL CHALLENGE” PROJECT LED BY DR. JULIEN GIGAULT (CNRS)

THANKS TO ITS DIRECT EXPOSITION TO THE NORTH-ATLANTIC GYRE, GUADELOUPE (FRENCH WEST INDIES) IS A FAVOURABLE LOCATION TO STUDY MARINE MICROPLASTIC WEATHERING AND ITS NANOSCALE DEGRADATION. #7ECONTINENT

The aim of the expedition was to first collect some samples on the beach and also from seawater. Following specific protocols, those samples were then analyzed with, among others, our nanoparticles size analyzer Vasco Flex™ for primary verifications and characterization. Boris Pedrono went there to help for samples collection and protocol optimization.

Further analysis on a huge quantity of collected samples will be conducted by several French teams. The results of this campaign should be published very soon. Stay tuned !

Projet nanotrans - Cordouan

NANOTRANS (TRANSPORT OF SOFT MATTER AT THE NANOSCALE) : A NEW HORIZON 2020 / MARIE SK?ODOWSKA-CURIE EUROPEAN TRAINING NETWORK

15 “EARLY STAGE RESEARCHER” (ESR) POSITIONS AVAILABLE (I.E. PHD POSITIONS) SPREAD ACROSS ALL ACADEMIC AND INDUSTRIAL PARTNERS

NANOTRANS involves ten universities and research organizations, as well as two industrial companies across Europe. Its scientific objective is to obtain a fundamental understanding of the transport of fluids and colloids at the nanoscale, covering experimental, theoretical and computational approaches to this problem.

 

projet snow - Cordouan

ADVANCED INSTRUMENTAL COUPLING : COMBINED SAXS/SANS + DLS MEASUREMENT

COMBINING SAXS AND DLS FOR SIMULTANEOUS MEASUREMENTS AND TIME-RESOLVED MONITORING OF NANOPARTICLE SYNTHESIS : AN EXAMPLE OF VASCO FLEX APPLICATIONS (VIDEO)

Cordouan Technologies contributed to the SNOW project with both of its devices. First with the VASCO FLEXTM for the particles size measurement and also with the WALLISTM 1 for the Zeta potentiel measurement, both in the characterisation phasis of this project.

The colloboration of Cordouan Technologies for the SNOW Project is now done. You will find following a link to a video that tells you more about this project.

1 – Manufactured in France by Cordouan Technologies