Come to see us at Pittcon 2020, this time in Chicago!
We will participate in Giornate Tecnologiche dedicated to different techniques and aspects of nanoparticle production organised by L’Associazione Italiana di Scienza e Tecnologia delle Macromolecole (AIM)
Come to see us at our booth at The SFNano – C’Nano joint meeting 2019. We will come with our youngest: the AMERIGO. We invite you as well to see the presentation of Floran Aubrit “Visible/NIR photothermia with gold bipyramids and nanostars”, the 11th December at 12h45 at the session “Nano-optics and nanophotonics 2”
It was a pleasure to visite our Polish distributor PIK Instruments at their Symposium & Workshop on Advanced Sample Preparation for Microscopy in Material Science. A great meeting!
Visit a booth of our czech distributor Pragolab at International Engineering Fair in Brno
Cordouan will present its new system AMERIGO at the booth of its representative Prolyse at LabTechnology in Utrecht.
Presentation of the latest development on Dynamic Light scattering by Cordouan Technologies
Cordouan Technologies will be represented by GMP during the ILMAC show 3-5 october 2018 in lausanne.
Visit ILMAC website and www.gmp.ch.
our new Vasco Kin will be presented.
Monitoring protein aggregation in injectable vaccines syringes: a new direct & contact-less technique
David Jacob CTO
Keywords: vaccines, protein, in situ measurement, aggregation
Aggregation of proteins and active principle ingredients (API) in injectable biopharmaceutical products remains a major concern impacting the stability and usability of a product. Indeed, Protein aggregation can occur during all stages of the lifetime of a protein therapeutic, including expression, refolding, purification,
sterilization, shipping, storage, and delivery processes [1, 2]. The mechanism of protein
aggregation is still not well understood; but it is known that certain manufacturing stages
like formulation composition, presence of microbial or vial contaminants during cell
culture, and storage influence the risk of chemical degradation, which increases the risk
of physical degradation and the formation of aggregates. In particular, it has been shown
that the storage container environment plays a role like in prefilled syringes for example
where leaking silicone oil from the rubber stopper, and glass delamination can induce
aggregates. In a context of more and more stringent international health regulations
about the control of biopharmaceutical products, the in-situ monitoring of the denaturation and degradation process of therapeutic proteins during production and storage can be a key competitive advantage for manufacturers and researchers