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Cancer therapy improvement with mesoporous silica nanoparticles combining targeting, drug delivery and PDT

ABD

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Industry: Nanomedicine
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Instrument: Vasco

Industry: Nanomedicine

DOI: https://doi.org/10.1016/j.ijpharm.2011.11.045

Keywords: Mesoporous Silica Nanoparticles, Photodynamic therapy, Targeting, Drug delivery, Carbohydrates

The synthesis of Mesoporous Silica Nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. (371 characters)
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With a single and continuous measurement, VASCO KIN™ gives you access to all characterization data of your reaction (size distribution evolution over time).