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Nanocarrier systems assembled from PEGylated hyperbranched poly(arylene oxindole)

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Industry: Nanomedicine
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Instrument: Vasco, Wallis

Industry: Nanomedicine

DOI: https://doi.org/10.1016/j.eurpolymj.2019.07.029

Keywords: PEGylation; hyperbranched polymers; cisplatin; drug release; nanomaterials; cellular uptake

Nanoparticles (NPs) formed from hyperbranched polymers are highly attractive organized structures in nanomedicine. Herein, we utilize copper-catalyzed azide-alkyne cycloaddition of hyperbranched poly(arylene oxindole) derivatives to prepare amphiphilic conjugates with different degrees of PEGylation that form spherical NPs in water with tunable particle diameters (25 ± 5 nm for PEG0.3-NPs and 120 ± 10 nm for PEG0.1-NPs) and zeta potential (−7 ± 2 mV for PEG0.3-NPs and −23 ± 3 mV for PEG0.1-NPs). (441 characters)
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