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Optimizing the synthesis and purification of MS2 virus like particles

ABD

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Industry: Nanomedicine
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Instrument: Vasco

Industry: Nanomedicine

DOI: https://doi.org/10.1021/acs.cgd.2c01237 https://doi.org/10.1038/s41598-021-98706-1

Keywords: MS2 virus-like particles, drug delivery

Introducing bacteriophage MS2 virus-like particles (VLPs) as gene and drug delivery tools increases the demand for optimizing their production and purification procedure. PEG precipitation method is used efficiently to purify VLPs, while the effects of pH and different electrolytes on the stability, size, and homogeneity of purified MS2 VLPs, and the encapsulated RNA sequences remained to be elucidated. (342 characters)
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With a single and continuous measurement, VASCO KIN™ gives you access to all characterization data of your reaction (size distribution evolution over time).